What can be done to improve the economy of upstate New York?

The cities in upstate New York have been stagnant or declining for the past 50 years or so. What can be done to improve the local economy of this region, and convert the cities of Buffalo, Syracuse, Rochester, Utica and Albany to bustling urban centers? Do these cities have a strategic value due to their proximity to the Northeast corridor, the heart of Canada and the St. Lawrence Seaway? Could a large scale public works project aimed at improving the shipping capacity of the Great Lakes region, coupled with increased freight capabilities to and from the region and nearby urban centers provide logistical benefits to industry and comerce? All and all, what has to give for these cities to flourish?

Answer:
I've read that upstate NY has relatively high taxes for individuals and businesses as well as high costs for utilities, worker's comp, health insurance and such. These are less of a handicap for NYC but for startup businesses in small cities and towns these can be devastating.

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