Is it possible for an aircraft cabin to be fully sealed and oxygenated like a spacecraft?

have engineers tested a fully sealed and oxygenated aircraft cabin before? what were the effects on the pilot?

Answer:
Yes, it is possible, but not practical. It is expensive to build a completely sealed system, a lot harder to maintain, and in an airplane's case it just is not necessary in the first place.

All commercial airliners are pressurized. With pressurization, the need to seal an aircraft is eliminated. Think of it like a leaky balloon: air is always getting out. But if you can keep more air going in, it stays pressurized and keeps it's shape. The airplane can always get more air, it's swimming in it.

In real life it's much easier, safer, and practical to make an airplane pressurized rather than sealed.
An aircraft cabin is already pressurized and is sealed.It has to be at such altitudes or else your Aircraft will go bonkers and be reduced to paper mache.
I don't believe that an aircraft cabin is totally sealed, but it is ventilated. It just takes in more air than it lets out such that it maintains positive pressure in the cabin.

There is a control system that regulates this, and if it fails low it drops the oxygen masks to prevent the occupants from suffering O2 deprivation.

Oxygen levels are not manipulated because the air that it takes in is 21% oxygen just like we like it.

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